Bisphenol A Low Dose Hypothesis Unproven
Bisphenol A (BPA) is an important industrial chemical that is used primarily to make polycarbonate plastic and epoxy resins, both of which are used in a wide variety of applications. The potential toxicity of BPA has been examined extensively with numerous safety studies conducted over more than 40 years. These studies uniformly have shown that the toxicity of BPA is low, as assessed by standard test protocols. Exposure evaluations have demonstrated a large margin of safety between any realistic exposure levels of BPA and any level of concern. Taken together, these tests and evaluations demonstrate that consumer exposure to BPA does not pose any risk to human health.
In recent years, a hypothesis has been advanced claiming that exposure to extremely low doses of certain substances could cause adverse health effects in humans. According to this "low-dose hypothesis", health effects occur at doses far below levels previously determined to be safe using well-established toxicological procedures and principles. This hypothesis further asserts that health effects may only be observed at low doses while much higher doses result in no effects, which is contrary to a fundamental principle of toxicology-"the dose makes the poison."
Since the initial claims of low-dose health effects of BPA were first reported in the mid- 1990s, many studies have been conducted to test the validity of the low-dose hypothesis. Included are definitive, large-scale, multi-generation studies as well as studies aimed at replicating the results of studies reporting low-dose effects. No low-dose effects were found in these studies, thus clearly demonstrating that the low-dose hypothesis is not valid.
The weight of scientific evidence clearly supports the safety of BPA and provides strong reassurance that there is no basis for human health concerns from exposure to low doses of BPA.
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