Table 3. Testing of Selected Workplace Chemicals for Teratatogenic Potential (Hardin et al., 1981).
| Dose Level (mg/kg/day) | 0 |
85 |
125 |
| # Animals/Group | 12 |
4 |
12 |
| Maternal Effects | No |
No |
Yes (see text) |
| # Pregnant/# Inseminated | 11/12 |
4/4 |
3/12 (a) |
| Implants per Female | 11 |
8 |
5 (b) |
| Implants as % of Corpora Lutea | 88.5 |
72.3 |
39.5 |
| Living Fetuses/Female | 11 |
7 (b) |
4 (b) |
| Dead or Resorbed Implants per Female | 0.4 |
1.25 |
1.33 |
| Dead or Resorbes as % of Implants | 4 |
14.7 |
26.7 |
| Fetal Body Weight (g) | 3.97 |
2.58 |
2.39 (c) |
| Fetal Crown-Rump Length (cm) | 3.9 |
3.4 |
3.2 (c) |
| Sex Ratio (M:F) | 65:54 |
15:14 |
8:3 |
| External Obs. (Examined/Affected) | 118/3 |
29/0 |
11/3 (d) |
| Skeletal Obs. (Examined/Affected) | 57/11 |
14/10 (c) |
5/5 (c) |
| Visceral Obs. (Examined/Affected) | 61/2 |
15/11 (c) |
6/6 (c) |
Note: Maternal body weight and food consumption parameters were not included in this publication.
(a) Differs significantly from controls (p = 0.0014)
(b) Differs significantly from controls (p <.02)
(c) Differs significantly from controls (p<0.001)
(d) Differs significantly from controls (p>0.01)
Notes: Severe flaws in this study include the following: non-relevant route of exposure; excess mortality and maternal toxicity (peritonitis); litter size too small; difficult to separate effects from disease process; and the purity of test material is unknown.
Based upon the several factors that confound its interpretation, this study is not useful for risk assessment purposes.