Table 3. Testing of Selected Workplace Chemicals for Teratatogenic Potential (Hardin et al., 1981).

Dose Level (mg/kg/day)

0

85

125

# Animals/Group

12

4

12

Maternal Effects

No

No

Yes (see text)

# Pregnant/# Inseminated

11/12

4/4

3/12 (a)

Implants per Female

11

8

5 (b)

Implants as % of Corpora Lutea

88.5

72.3

39.5

Living Fetuses/Female

11

7 (b)

4 (b)

Dead or Resorbed Implants per Female

0.4

1.25

1.33

Dead or Resorbes as % of Implants

4

14.7

26.7

Fetal Body Weight (g)

3.97

2.58

2.39 (c)

Fetal Crown-Rump Length (cm)

3.9

3.4

3.2 (c)

Sex Ratio (M:F)

65:54

15:14

8:3

External Obs. (Examined/Affected)

118/3

29/0

11/3 (d)

Skeletal Obs. (Examined/Affected)

57/11

14/10 (c)

5/5 (c)

Visceral Obs. (Examined/Affected)

61/2

15/11 (c)

6/6 (c)

Note: Maternal body weight and food consumption parameters were not included in this publication.

(a) Differs significantly from controls (p = 0.0014)

(b) Differs significantly from controls (p <.02)

(c) Differs significantly from controls (p<0.001)

(d) Differs significantly from controls (p>0.01)

Notes: Severe flaws in this study include the following: non-relevant route of exposure; excess mortality and maternal toxicity (peritonitis); litter size too small; difficult to separate effects from disease process; and the purity of test material is unknown.

Based upon the several factors that confound its interpretation, this study is not useful for risk assessment purposes.