Tables 4a and 4b. Bisphenol A: Reproduction and Fertility Assessment in CD-1 Mice When Administered Via Subcutaneous Silastic Implants ( Reel et al. 1984,)

Table 4a - TASK 1. Two-week Continuous Administration Range-Finding Study For Continuous Breeding Study in Mice. (Single Silastic Implant)

Dose Level (mg)

(5/Sex/Group)

0

6.25

12.5

25.0

50.0

100

Mortality (%)

0

0

0

0

0

0

Final Male Body Wt. (g)

37.9

36.0

35.5

37.1

36.7

37.5

Final Female Body Wt. (g)

27.5

28.2

27.4

27.9

28.1

28.2

Female Repro. Tract Wt. (g)

159.0

175.6

179.0

186.4

146.6

241.3 (a)

(a) Author suggest that heavier reproductive tract weight may be due to estrogenic activity.


Table 4b - TASK 2. Continuous Breeding Phase, Consisting of a 7-Day Premating Exposure, 98-Day Cohabitation Period and a 21-Day Segregation Period. (Single Silastic Implant)

Dose Level (mg)

(#/Sex/Group)

0

(40)

25

(20)

50

(20)

100

(20)

  M F M F M F M F
Body Weight (Week 1) (g) 37.7 29.0 37.1 28.4 37.6 29.1 37.8 28.8
Body Weight (Week 18) (g) 40.2 37.2 39.8 36.9 39.8 38.9 39.1 37.7
No. Fertile/No. Cohabited 38/39 19/20 19/19 20/20
Fertility Index (%) 97 95 100 100
# Litters/pair 4.39 4.26 4.53 4.45
# Live Pups/Litter (Comb. M/F) 9.93 9.54 10.66 9.49
% Pups Born Alive 100 99 95 99
Live Pup Weight (g) 1.68 1.67 1.68 1.75
Female Repro. Tract Wt. (Mg) 393 - - 383
L. Testis & Epididymis Wt (mg) 193.0 - - 194.0
R. Testis Weight (mg) 137.0 - - 137.0
R. Epididymis (mg) 58.0 - - 59.0
Prostrate (mg) 57.0 - - 58.0
Seminal Vesicle Weight (mg) 434.0 - - 432.0

Notes: Indications of non-estrogenicity include no significant changes in no. fertile per no. cohabited, fertility index, no. litters per pair, no. live pups per litter, % pups born alive, and the weight of live pups, female reproductive tract, testis, epididymis, prostate and seminal vesicles. There were no indications of estrogenicity.

Based upon the lack of a dose response and irrelevant route of exposure, this study is inadequate for risk assessment purposes.