Tables 4a and 4b. Bisphenol A: Reproduction and Fertility Assessment in CD-1 Mice When Administered Via Subcutaneous Silastic Implants ( Reel et al. 1984,)
Table 4a - TASK 1. Two-week Continuous Administration Range-Finding Study For Continuous Breeding Study in Mice. (Single Silastic Implant)
| Dose Level (mg) (5/Sex/Group) |
0 |
6.25 |
12.5 |
25.0 |
50.0 |
100 |
| Mortality (%) | 0 |
0 |
0 |
0 |
0 |
0 |
| Final Male Body Wt. (g) | 37.9 |
36.0 |
35.5 |
37.1 |
36.7 |
37.5 |
| Final Female Body Wt. (g) | 27.5 |
28.2 |
27.4 |
27.9 |
28.1 |
28.2 |
| Female Repro. Tract Wt. (g) | 159.0 |
175.6 |
179.0 |
186.4 |
146.6 |
241.3 (a) |
(a) Author suggest that heavier reproductive tract weight may be due to estrogenic activity.
Table 4b - TASK 2. Continuous Breeding Phase, Consisting of a 7-Day Premating Exposure, 98-Day Cohabitation Period and a 21-Day Segregation Period. (Single Silastic Implant)
| Dose Level (mg) (#/Sex/Group) |
0 (40) |
25 (20) |
50 (20) |
100 (20) |
||||
| M | F | M | F | M | F | M | F | |
| Body Weight (Week 1) (g) | 37.7 | 29.0 | 37.1 | 28.4 | 37.6 | 29.1 | 37.8 | 28.8 |
| Body Weight (Week 18) (g) | 40.2 | 37.2 | 39.8 | 36.9 | 39.8 | 38.9 | 39.1 | 37.7 |
| No. Fertile/No. Cohabited | 38/39 | 19/20 | 19/19 | 20/20 | ||||
| Fertility Index (%) | 97 | 95 | 100 | 100 | ||||
| # Litters/pair | 4.39 | 4.26 | 4.53 | 4.45 | ||||
| # Live Pups/Litter (Comb. M/F) | 9.93 | 9.54 | 10.66 | 9.49 | ||||
| % Pups Born Alive | 100 | 99 | 95 | 99 | ||||
| Live Pup Weight (g) | 1.68 | 1.67 | 1.68 | 1.75 | ||||
| Female Repro. Tract Wt. (Mg) | 393 | - | - | 383 | ||||
| L. Testis & Epididymis Wt (mg) | 193.0 | - | - | 194.0 | ||||
| R. Testis Weight (mg) | 137.0 | - | - | 137.0 | ||||
| R. Epididymis (mg) | 58.0 | - | - | 59.0 | ||||
| Prostrate (mg) | 57.0 | - | - | 58.0 | ||||
| Seminal Vesicle Weight (mg) | 434.0 | - | - | 432.0 | ||||
Notes: Indications of non-estrogenicity
include no significant changes in no. fertile per no. cohabited, fertility index,
no. litters per pair, no. live pups per litter, % pups born alive, and the weight
of live pups, female reproductive tract, testis, epididymis, prostate and seminal
vesicles. There were no indications of estrogenicity.
Based upon the lack of a dose response and irrelevant route of exposure, this
study is inadequate for risk assessment purposes.