Table 6a. Teratologic Evaluation of Bisphenol A (CAS No. 80-05-7) Administered to CD (R) Rats on Gestational Days 6 Through 15 (George et al., 1985).
| Dose Level
(mg/kg/day) (8/group) |
0 |
500 |
1000 |
1500 |
2000 |
2500 |
3000 |
| Mortality | 0/8 |
0/8 |
0/8 |
1/8 |
5/8 |
3/8 |
5/8 |
| % Pregnant at Sacrifice | 100 |
100 |
87.5 |
100 |
100 |
100 |
100 |
| Maternal Weight
Gain (Gestation) (g) |
118.35 |
102.88 |
90.41 (a) |
85.71 (a) |
55.49 (a) |
24.56 (b) |
37.61 (b) |
| Gravid Uterine Weight (mg) | 67.35 |
73.44 |
55.80 |
61.41 |
37.10 (a) |
18.40 (a) |
50.45 |
| Implantation Sites/Litter | 12.38 |
13.25 |
11.86 |
13.57 |
12.33 |
13.00 |
14.50 |
| % Resorptions/Litter | 4.24 |
5.84 |
10.11 |
11.31 |
42.90 (a) |
74.05 (a) |
15.65 (b) |
| % Litters with Resorptions | 37.5 |
37.5 |
71.4 |
100 |
100 |
100 |
50.0 |
| % Dead Fetuses/Litter | 0.89 |
0 |
0 |
0 |
0 |
1.78 |
3.15 |
| % Litters with Dead Fetuses | 12.5 |
0 |
0 |
0 |
0 |
25.0 |
33.3 |
| % Nonlive Implants/Litter | 5.14 |
5.84 |
10.11 |
11.31 |
42.90 (b) |
75.83 (b) |
18.75 |
| % Litters with Affected Fetuses | 37.5 |
37.5 |
71.4 |
100.0 |
100.0 |
100.0 |
50.0 |
| Live Fetuses/Litter | 11.63 |
12.63 |
10.71 |
12.14 |
7.00 |
4.67 |
11.50 |
| Average Fetal Body Weight (g) | 3.67 |
3.75 |
3.11 (a) |
3.00 (b) |
2.79 (a) |
2.73 (a) |
2.36 (a) |
| % Fetuses Malformed | 0 |
0 |
0 |
0 |
0.05 |
0 |
0 |
| % Litters with Malformed | 0 |
0 |
0 |
0 |
0.33 |
0 |
0 |
| % Fetuses Malformed/Litter | 0 |
0 |
0 |
0 |
0.11 |
0 |
0 |
(a) Significantly different (p <0.05)
(b) Significantly different (p <0.01)
Note: No significant effects were observed in the absence of generalized maternal toxicity. The maternal and fetal NOEL of the study is 500 mg/kg/day.
Table 6b Teraltologic Evaluation
There is no maternal and fetal NOEL for this study is 500 mg/kg/day. For risk assessment purposes, this study is superceded by the 90-day reproduction andd toxicity studies conducted by Wazeter, 1976 (Table 1) and Goldenthal, 1978 (Table 2), which estimated the maternal NOEL to be 50 mg/kg/day.