Table 6a. Teratologic Evaluation of Bisphenol A (CAS No. 80-05-7) Administered to CD (R) Rats on Gestational Days 6 Through 15 (George et al., 1985).

Dose Level (mg/kg/day)

(8/group)

0

500

1000

1500

2000

2500

3000

Mortality

0/8

0/8

0/8

1/8

5/8

3/8

5/8

% Pregnant at Sacrifice

100

100

87.5

100

100

100

100

Maternal Weight Gain

(Gestation) (g)

118.35

102.88

90.41 (a)

85.71 (a)

55.49 (a)

24.56 (b)

37.61 (b)

Gravid Uterine Weight (mg)

67.35

73.44

55.80

61.41

37.10 (a)

18.40 (a)

50.45

Implantation Sites/Litter

12.38

13.25

11.86

13.57

12.33

13.00

14.50

% Resorptions/Litter

4.24

5.84

10.11

11.31

42.90 (a)

74.05 (a)

15.65 (b)

% Litters with Resorptions

37.5

37.5

71.4

100

100

100

50.0

% Dead Fetuses/Litter

0.89

0

0

0

0

1.78

3.15

% Litters with Dead Fetuses

12.5

0

0

0

0

25.0

33.3

% Nonlive Implants/Litter

5.14

5.84

10.11

11.31

42.90 (b)

75.83 (b)

18.75

% Litters with Affected Fetuses

37.5

37.5

71.4

100.0

100.0

100.0

50.0

Live Fetuses/Litter

11.63

12.63

10.71

12.14

7.00

4.67

11.50

Average Fetal Body Weight (g)

3.67

3.75

3.11 (a)

3.00 (b)

2.79 (a)

2.73 (a)

2.36 (a)

% Fetuses Malformed

0

0

0

0

0.05

0

0

% Litters with Malformed

0

0

0

0

0.33

0

0

% Fetuses Malformed/Litter

0

0

0

0

0.11

0

0

(a) Significantly different (p <0.05)

(b) Significantly different (p <0.01)

Note: No significant effects were observed in the absence of generalized maternal toxicity.  The maternal and fetal NOEL of the study is 500 mg/kg/day.

Table 6b  Teraltologic Evaluation

There is no maternal and fetal NOEL for this study is 500 mg/kg/day. For risk assessment purposes, this study is superceded by the 90-day reproduction andd toxicity studies conducted by Wazeter, 1976 (Table 1) and Goldenthal, 1978 (Table 2), which estimated the maternal NOEL to be 50 mg/kg/day.