Table 7a. Teratological Evaluation of Bisphenol A (CAS No. 80-05-7) Administered to CD-1 Mice on Gestational Days 6 Through 15 ( George et al., 1985a).
Preliminary Toxicity Study (Range-Finder)
| Dose Level (mg/kg/day) (8/group) |
0 |
250 |
500 |
750 |
1000 |
1250 |
| Mortality | 0/8 |
0/8 |
2/8 |
1/8 |
1/8 |
2/8 |
| % Pregnant at Sacrifice | 86 |
92 |
100 |
92 |
83 |
77 |
| Maternal Wt. Gain (Gestation) (g) | 20.84 |
22.61 |
23.32 |
20.86 |
19.97 |
10.99 (b) |
| Gravid Uterine Weight (g) | 15.40 |
15.80 |
16.56 |
16.46 |
15.33 |
8.50 (b) |
| Implantation Sites/Litter | 12.08 |
11.58 |
13.00 |
13.27 |
13.10 |
11.60 |
| % Resorption/Litter | 8.7 |
5.5 |
7.7 |
5.4 |
6.9 |
43.0 |
| % Litters with Resorptions | 66.7 |
41.7 |
75.0 |
63.6 |
50.0 |
80.0 |
| % Dead Fetuses/Litter | 1.3 |
1.4 |
0.0 |
2.2 |
2.4 |
1.8 |
| % Litters with Dead Fetuses | 16.7 |
16.7 |
0.0 |
18.2 |
20.0 |
20.0 |
| % Nonlive/Litter | 10.0 |
6.9 |
7.7 |
7.6 |
9.4 |
44.9 |
| % Litters with Nonlive Implants | 75.0 |
41.7 |
75.0 |
72.7 |
70.0 |
90.0 |
| Live Fetuses/Litter | 10.92 |
10.75 |
12.00 |
12.27 |
11.90 |
10.83 |
| Average Fetal Body Weight (g) | 0.942 |
0.988 |
0.930 |
0.908 |
0.819 |
0.743 (b) |
| % Fetuses Malformed | 0 |
0 |
0 |
0.74 |
4.2 |
1.53 |
| % Litters with Malformed | 0 |
0 |
0 |
9.09 |
10.0 |
16.66 |
| % Fetuses Malformed/Litter | 0 |
0 |
0 |
0.7 |
3.9 |
1.4 |
(a) Significantly different (p<0.05)
(b) Significantly different (p<0.01)
Note: No significant effects were observed in the absence of generalized maternal toxicity. For this study, the maternal NOEL is 250 mg/kg/day and the fetal NOEL is 1000 mg/kg/day.
Table 7b. Teratological Evaluation of Bisphenol A (CAS No. 80-05-7) Administered to CD-1 Mice on Gestational Days 6 Through 15 ( George et al., 1985a).
Definitive Teratology Study
| Dose Level (mg/kg/day) (# Treated/group) |
0 (29) |
500 (29) |
750 (29) |
1000 (34) |
1250 (33) |
| # Dead | 0 |
2 |
1 |
2 |
6 |
| % Pregnant at Sacrifice | 89.7 |
88.5 |
77.8 |
76.7 |
77.8 |
| Maternal Wt. Gain (Gestation) (g) | 19.78 |
21.80 |
20.73 |
18.08 |
13.47 (a) |
| Gravid Uterine Weight (g) | 14.73 |
15.61 |
14.82 |
13.43 |
9.96 (a) |
| Corpora Lutea/Dam | 11.88 |
11.77 |
11.84 |
10.05 |
9.16 |
| Implantation Sites/Litter | 11.88 |
12.30 |
11.71 |
12.09 |
11.81 |
| % Resorptions/Litter | 14.13 |
12.86 |
7.5 |
18.42 |
40.14 (a) |
| % Litters with Resorptions | 69.2 |
60.9 |
61.9 |
52.2 |
81.0 |
| % Dead Fetuses/Litter | 0.60 |
0.00 |
2.03 |
2.69 |
0.87 |
| % Litters with Dead Fetuses | 7.7 |
0.0 |
19.0 |
17.4 |
9.5 |
| % Nonlive Implants/Litter | 14.73 |
12.86 |
9.53 |
21.12 |
41.02 (a) |
| % Litters with Nonlive Implants | 73.1 |
60.9 |
71.4 |
65.2 |
85.7 |
| % Affected Fetuses/Litter | 16.95 |
15.11 |
10.80 |
25.57 |
44.69 (a) |
| Live Fetuses/Litter | 10.76 |
11.55 |
10.67 |
11.20 |
10.93 |
| Males/Litter | 5.68 |
5.82 |
5.00 |
5.90 |
5.43 |
| Females/Litter | 5.08 |
5.73 |
5.67 |
5.30 |
5.50 |
| Average Fetal Body Weight (g) | 0.955 |
0.943 |
0.943 |
0.869 |
0.820 |
| Gross Malformations/Litter | 0.00 |
0.09 |
0.10 |
0.55 |
0.29 |
| Visceral Malformations/Litter | 0.20 |
0.14 |
0.05 |
0.20 |
0.07 |
| Skeletal Malformations/Litter | 0.08 |
0.09 |
0.05 |
0.15 |
0.50 |
| % Fetuses Malformed/Litter | 2.70 |
2.44 |
1.28 |
5.69 |
5.79 |
| % Fetuses Malformed | 2.60 |
2.76 |
1.34 |
6.70 |
7.19 |
| % Litters with Malformed | 24.00 |
27.27 |
14.29 |
15.00 |
42.86 |
(a) Significantly different (p<0.05)
(b) Significantly different (p<0.01)
Note: No significant effects were observed in the absence of generalized maternal toxicity. The maternal and fetal NOEL for this study is 1000 mg/kg/day.