Table 7a. Teratological Evaluation of Bisphenol A (CAS No. 80-05-7) Administered to CD-1 Mice on Gestational Days 6 Through 15 ( George et al., 1985a).

Preliminary Toxicity Study (Range-Finder)

Dose Level (mg/kg/day)

(8/group)

0

250

500

750

1000

1250

Mortality

0/8

0/8

2/8

1/8

1/8

2/8

% Pregnant at Sacrifice

86

92

100

92

83

77

Maternal Wt. Gain (Gestation) (g)

20.84

22.61

23.32

20.86

19.97

10.99 (b)

Gravid Uterine Weight (g)

15.40

15.80

16.56

16.46

15.33

8.50 (b)

Implantation Sites/Litter

12.08

11.58

13.00

13.27

13.10

11.60

% Resorption/Litter

8.7

5.5

7.7

5.4

6.9

43.0

% Litters with Resorptions

66.7

41.7

75.0

63.6

50.0

80.0

% Dead Fetuses/Litter

1.3

1.4

0.0

2.2

2.4

1.8

% Litters with Dead Fetuses

16.7

16.7

0.0

18.2

20.0

20.0

% Nonlive/Litter

10.0

6.9

7.7

7.6

9.4

44.9

% Litters with Nonlive Implants

75.0

41.7

75.0

72.7

70.0

90.0

Live Fetuses/Litter

10.92

10.75

12.00

12.27

11.90

10.83

Average Fetal Body Weight (g)

0.942

0.988

0.930

0.908

0.819

0.743 (b)

% Fetuses Malformed

0

0

0

0.74

4.2

1.53

% Litters with Malformed

0

0

0

9.09

10.0

16.66

% Fetuses Malformed/Litter

0

0

0

0.7

3.9

1.4

(a) Significantly different (p<0.05)

(b) Significantly different (p<0.01)

Note: No significant effects were observed in the absence of generalized maternal toxicity. For this study, the maternal NOEL is 250 mg/kg/day and the fetal NOEL is 1000 mg/kg/day.


Table 7b. Teratological Evaluation of Bisphenol A (CAS No. 80-05-7) Administered to CD-1 Mice on Gestational Days 6 Through 15 ( George et al., 1985a).

Definitive Teratology Study

Dose Level (mg/kg/day)

(# Treated/group)

0

(29)

500

(29)

750

(29)

1000

(34)

1250

(33)

# Dead

0

2

1

2

6

% Pregnant at Sacrifice

89.7

88.5

77.8

76.7

77.8

Maternal Wt. Gain (Gestation) (g)

19.78

21.80

20.73

18.08

13.47 (a)

Gravid Uterine Weight (g)

14.73

15.61

14.82

13.43

9.96 (a)

Corpora Lutea/Dam

11.88

11.77

11.84

10.05

9.16

Implantation Sites/Litter

11.88

12.30

11.71

12.09

11.81

% Resorptions/Litter

14.13

12.86

7.5

18.42

40.14 (a)

% Litters with Resorptions

69.2

60.9

61.9

52.2

81.0

% Dead Fetuses/Litter

0.60

0.00

2.03

2.69

0.87

% Litters with Dead Fetuses

7.7

0.0

19.0

17.4

9.5

% Nonlive Implants/Litter

14.73

12.86

9.53

21.12

41.02 (a)

% Litters with Nonlive Implants

73.1

60.9

71.4

65.2

85.7

% Affected Fetuses/Litter

16.95

15.11

10.80

25.57

44.69 (a)

Live Fetuses/Litter

10.76

11.55

10.67

11.20

10.93

Males/Litter

5.68

5.82

5.00

5.90

5.43

Females/Litter

5.08

5.73

5.67

5.30

5.50

Average Fetal Body Weight (g)

0.955

0.943

0.943

0.869

0.820

Gross Malformations/Litter

0.00

0.09

0.10

0.55

0.29

Visceral Malformations/Litter

0.20

0.14

0.05

0.20

0.07

Skeletal Malformations/Litter

0.08

0.09

0.05

0.15

0.50

% Fetuses Malformed/Litter

2.70

2.44

1.28

5.69

5.79

% Fetuses Malformed

2.60

2.76

1.34

6.70

7.19

% Litters with Malformed

24.00

27.27

14.29

15.00

42.86

(a) Significantly different (p<0.05)

(b) Significantly different (p<0.01)

Note: No significant effects were observed in the absence of generalized maternal toxicity. The maternal and fetal NOEL for this study is 1000 mg/kg/day.