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bisphenol a and toxicological research
Toxicology Research on Bisphenol A

Toxicology is the study of the harmful actions of agents on biological mechanisms. The toxicological effects of bisphenol A are well understood. One of the most extensively tested materials in use today, BPA exhibits toxic effects only at very high exposures.

CARCINOGENICITY  
NTP Technical Report on the Carcinogenesis Bioassay of Bisphenol A. National Toxicology Program. 1982. Technical Report Series No. 215. Summary and full report available at: NTP
   
An Evaluation of the Possible Carcinogenicity of Bisphenol A to Humans. Haighton, L.A., et al. 2002. J. Reg. Toxicol. Pharmacol. 35: 238-254. Abstract available at: Science Direct
   
REPRODUCTIVE AND DEVELOPMENTAL  
Weight of the Evidence Evaluation of Low-Dose Reproductive and
Developmental Effects of Bisphenol A. Gray, G. M., et al. 2004. Human
and Ecological Risk Assessment. 10(5):875-921. Copyright 2004 From Human and Ecological Risk Assessment by George M. Gray. Reproduced by permission of Taylor & Francis, Inc., http://www.taylorandfrancis.com. Full Text (194kb, PDF)
   
The Developmental Toxicity of Bisphenol A in Rats and Mice. Morrissey, R.E. et al. 1987. Fund. Appl. Toxicol. 8: 571-582. Originally published by Oxford University Press. Full text (984kb, PDF)
   
Three-Generation Reproductive Toxicity Study of Dietary Bisphenol A in CD Sprague-Dawley Rats. Tyl, R.W., et al. 2002. Toxicological Sciences. 68(1):121-146. Abstract and full text available at: Oxford Jounals Online
   
Rat Two-Generation Reproductive Toxicity Study of Bisphenol-A. Ema, M. 2001. Reproductive Toxicology. 15(5):505-523. Abstract available at: Science Direct
   
ENDOCRINE ACTIVITY  
Normal Reproductive Organ Development in CF-1 Mice Following Prenatal Exposure to Bisphenol A. Cagen, S.Z. et al. 1999. Toxicol. Sci. 50:36-44. Full Text (128kb, PDF)
   
Normal Reproductive Organ Development in Wistar Rats Exposed to Bisphenol A in Drinking Water. Cagen, S.Z. et al. 1999. Regul. Toxicol. Pharmacol. 30(2 Pt 1):130-9. Abstract available at: Science Direct
   
PHARMACOKINETICS  
The Relative Bioavailability and Metabolism of Bisphenol A in Rats Is Dependent upon the Route of Administration. Pottenger, L.H. et al. 2000. Toxicol. Sci. 54(1):3-18. Abstract and full text available at: Oxford Journals Online
   
To obtain reprints of specific papers, contact the publisher directly.

   
 

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